QSAR and Synthesis of a Novel Biphenyl Carboxamide Analogue for Analgesic Activity

A compound 2-(anilino)-1-(4-phenylphenyl)ethanone was synthesized by reaction between biphenyl acid chloride and aniline. The synthesized compound was screened for analgesic activity. The selection of the compound was on the basis of QSAR study performed on the biphenyl analogs having anti-inflammatory activity. 2D QSAR study using topological descriptors revealed the important features required for the design of new potent anti-inflammatory agent. QSAR equation found in present study had r2 of 0.842 and internal predictivity of 0.69. Using QSAR results a molecule was designed to have analgesic activity. *Corresponding author: Prasanna Datar, Sinhgad Institute of Pharmacy, Narhe, Pune, 411041, Maharashtra, India, Tel: 91-9823-161-187; E-mail: [email protected] Received January 21, 2015; Accepted January 20, 2015; Published January 25, 2015 Citation: Datar P (2015) QSAR and Synthesis of a Novel Biphenyl Carboxamide Analogue for Analgesic Activity. Mod Chem appl 3: 148. doi:10.4172/23296798.1000148 Copyright: © 2015 Datar P. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.